Gilad Lab | MSU

Publications

2022

Lee HD, Grady CJ, Krell K, Strebeck C, Good NM, Martinez-Gomez NC, Gilad AA. A Novel Protein for the Bioremediation of Gadolinium Waste. bioRxiv. 2023.01.05.522788; doi: https://doi.org/10.1101/2023.01.05.522788

Ricker B, Mitra S, Castellanos EA, Grady CJ, Pelled G, Gilad AA. Proposed three-phenylalanine motif involved in magnetoreception signaling of an Actinopterygii protein expressed in mammalian cells. bioRxiv. 2022 December 09. https://doi.org/10.1101/2022.12.08.519643

Grady CJ, Schossau J, Ashbaugh RC, Pelled G, Gilad AA. A putative design for electromagnetic activation of split proteins for molecular and cellular manipulation. bioRxiv 2022 November 30. doi: https://doi.org/10.1101/2022.11.30.518522

Miralavy I, Bricco AR, Gilad AA, Banzhaf W. Using genetic programming to predict and optimize protein function. PeerJ Physical Chemistry 4:e24. 2022 September 21. https://doi.org/10.7717/peerj-pchem.24

Metto AC, Gilad AA, Pelled G. Magnetogenetic closed-loop reduction of seizure activity in a rat model of epilepsy. bioRxiv. 2022 August 22. https://doi.org/10.1101/2022.08.19.504501

Good NM, Lee HD, Hawker ER, Su MZ, Gilad AA. Martinez-Gomez NC. Hyperaccumulation of Gadolinium by Methylorubrum extorquens AM1 Reveals Impacts of Lanthanides on Cellular Processes Beyond Methylotrophy. Front. Microbiol., 17 March 2022. https://doi.org/10.3389/fmicb.2022.820327

Bricco AR, Miralavy I, Shaowei B, Perlman O, Farrar CT, McMahon MT, Banzhaf W, Gilad AA. Protein Optimization Evolving Tool (POET) based on Genetic Programming. bioRxiv 2022 March 06. https://doi.org/10.1101/2022.03.05.483103

Kanada M, Linenfelser L, Cox E, Gilad AA. A Dual-Reporter Platform for Screening Tumor-Targeted Extracellular Vesicles. Pharmaceutics 2022, 14(3), 475; 2022 February 22, https://doi.org/10.3390/pharmaceutics14030475

Gilad AA, Bar-shir A, Bricco AR, Mohanta Z, McMahon MT. Protein and peptide engineering for chemical exchange saturation transfer imaging in the age of synthetic biology. 2022 February 11. NMR Biomed. https://doi.org/10.1002/nbm.4712

2021

Petersen ED, Crespo EL, Lambert GG, Zanca AT, Orcutt R, Hochgeschwender U, Shaner NC, Gilad AA. Bioluminescent Genetically Encoded Glutamate Indicator for Molecular Imaging of Neuronal Activity. bioRxiv, 2021 June 16. https://doi.org/10.1101/2021.06.16.448690

Ashbaugh RC, Udpa L, Israeli RR, Gilad AA, Pelled G. Bioelectromagnetic platform for stimulation. bioRxiv 2021 June 7. https://doi.org/10.1101/2021.06.07.447412.

Desmet NM, Dhusia K, Qi W, Doseff AI, Bhattacharya S, Gilad AA*. Bioengineering of Genetically Encoded Gene Promoter Repressed by the Flavonoid Apigenin for Constructing Intracellular Sensor for Molecular Events. Biosensors, 2021 Apr 28;11(5):137. PMID: 33924783. https://doi.org/10.3390/bios11050137

Hunt R, Ashbaugh R, Reimers M, Udpa L, Saldana De Jimenez G, Moore M, Gilad AA, Pelled G. Swimming direction of the glass catfish is responsive to magnetic stimulation. PLOS ONE 2021 March 5;16(3): e0248141. https://doi.org/10.1371/journal.pone.0248141

2020

Cywiak C, Ashbaugh RC, Metto AC, Udpa L, Qian C, Gilad AA, Reimers, M, Zhong M, Pelled G. Non-invasive neuromodulation using rTMS and the electromagnetic-perceptive gene (EPG) facilitates plasticity after nerve injury, Brain Stimulation, 2020 Nov-Dec;13(6)1774-1783. Epub 2020 Oct 15. PMID: 33068795 PMCID: PMC7722061 https://doi.org/10.1016/j.brs.2020.10.006.

Perlman O, Ito H, Gilad AA, McMahon MT, Chiocca EA, Nakashima H, Farrar, CT. Redesigned reporter gene for improved proton exchange-based molecular MRI contrast. Sci Rep. 2020 Nov 26;10(1):20664. PMID: 33244130 PMCID: PMC7692519. https://doi.org/10.1038/s41598-020-77576-z.

Mitra S, Barnaba C, Schmidt J, Pelled G, Gilad AA*. Functional Characterization of an Electromagnetic Perceptive Protein. bioRxiv, 2020 October 07. https://doi.org/10.1101/2020.10.07.329946.

Hwang J, Choi Y, Lee K, Krishnan V, Pelled G, Gilad AA, Choi J. Regulation of Electromagnetic Perceptive Gene Using Ferromagnetic Particles for the External Control of Calcium Ion Transport. Biomolecules, 2020 Feb 15;10(2):308. https://doi.org/10.3390/biom10020308. PMID: 32075263 PMCID: PMC7072303

2018

Krishnan V, Park SA, Shin SS, Alon L, Tressler CM, Stokes W, Banerjee J, Sorrell ME, Tian Y, Fridman GY, Celnik P, Pevsner J, Guggino WB, Gilad AA, Pelled, G. Wireless control of cellular function by activation of a novel protein responsive to electromagnetic fields. Sci Rep. 2018 Jun 8;8(1):8764. https://doi.org/10.1038/s41598-018-27087-9. PubMed PMID: 29884813; PubMed Central PMCID: PMC5993716.

Krishnan V, Park SA, Shin SS, Alon L, Tressler CM, Stokes W, Banerjee J, Sorrell ME, Tian Y, Fridman GY, Celnik P, Pevsner J, Guggino WB, Gilad AA, Pelled, G. Wireless control of cellular function by activation of a novel protein responsive to electromagnetic fields. Sci Rep. 2018 Jun 8;8(1):8764. doi: 10.1038/s41598-018-27087-9. PubMed PMID: 29884813; PubMed Central PMCID: PMC5993716. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5993716/

Hwang J, Kim S, Seo Y, Lee K, Park C, Choi Y, Kim D, Gilad AA, Choi, J. Mechanisms of Salinity Control in Sea Bass. Biotechnology and Bioprocess Engineering. 2018 Jun;23(3):271-277. https://link.springer.com/article/10.1007/s12257-018-0049-3  

Seo Y, Park C, Son J, Lee K, Hwang J, Jo Y, Lee D, Khan MS, Chavan SG, Choi Y, Kim D, Gilad AA, Choi J. Synthesis of Multi-walled Carbon Nanotubes Modified with Silver Nanoparticles and Evaluation of Their Antibacterial Activities and Cytotoxic Properties. J Vis Exp. 2018 May 10;135. doi: 10.3791/57384. PubMed PMID: 29806837. https://www.jove.com/video/57384/synthesis-multi-walled-carbon-nanotubes-modified-with-silver

Hwang J, Lee K, Gilad AA, Choi J. Synthesis of Beta-glucan Nanoparticles for the Delivery of Single Strand DNA. Biotechnology and Bioprocess Engineering. 2018 Mar;23(2):144-149. https://link.springer.com/article/10.1007/s12257-018-0003-4

Lee D, Hwang J, Seo Y, Gilad AA, Choi J. Optical Immunosensors for the Efficient Detection of Target Biomolecules. Biotechnology and Bioprocess Engineering. 2018 Mar;23(2):123-133. https://link.springer.com/article/10.1007/s12257-018-0087-x

Meier S, Gilad AA, Brandon JA, Qian C, Gao E, Abisambra JF, Vandsburger M. Non-invasive detection of adeno-associated viral gene transfer using a genetically encoded CEST-MRI reporter gene in the murine heart. Sci Rep. 2018 Mar 15;8(1):4638. doi: 10.1038/s41598-018-22993-4. PubMed PMID: 29545551; PubMed Central PMCID: PMC5854573. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5854573/

Lina Alon, Dara L Kraitchman, Michael Schär, Angel Cortez, Nirbhay N Yadav, Rebecca Krimins, Peter V Johnston, Michael T McMahon, Peter CM van Zijl, Sridhar Nimmagadda, Martin G Pomper, Jeff WM Bulte, Assaf A Gilad. Molecular Imaging of CXCL12 Promoter-driven HSV1-TK Reporter Gene Expression. Biotechnology and Bioprocess Engineering. 2018 Mar 1;23(2):208-217 . doi 10.1007/s12257-018-0006-1. https://link.springer.com/article/10.1007/s12257-018-0006-1

Bar-Shir A, Alon L, Korrer MJ, Lim HS, Yadav NN, Kato Y, Pathak AP, Bulte JWM, Gilad AA.**Quantification and tracking of genetically engineered dendritic cells for studying immunotherapy. Magn Reson Med. 2018 Feb;79(2):1010-1019. doi: 10.1002/mrm.26708. Epub 2017 May 7. PubMed PMID: 28480589; PubMed Central PMCID:PMC5797672 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797672/

Hwang J, Son J, Seo Y, Jo Y, Lee K, Lee D, Khan MS, Chavan S, Park C, Sharma A, Gilad AA, Choi J. Functional silica nanoparticles conjugated with beta-glucan to deliver anti-tuberculosis drug molecules. Journal of Industrial and Engineering Chemistry. 2018 Feb 25;58:376-385. https://jhu.pure.elsevier.com/en/publications/functional-silica-nanoparticles-conjugated-with-beta-glucan-to-de

Lee D, Seo Y, Khan MS, Hwang J, Jo Y, Son J, Lee K, Park C, Chavan S, Gilad AA, Choi J. Use of Nanoscale Materials for the Effective Prevention and Extermination of Bacterial Biofilms. Biotechnology and Bioprocess Engineering. 2018 Feb;23(1):1-10. https://www.scopus.com/record/display.uri?eid=2-s2.0-85041004147&origin=inward&txGid=585b12fdeaafa471f85c3f4fecd05b9e

2017  

Gilad AA,**Shapiro MG. Molecular Imaging in Synthetic Biology, and Synthetic Biology in Molecular Imaging. Mol Imaging Biol. 2017 Jun 1;19(3):373-378. doi:10.1007/s11307-017-1062-1. Review. PubMed PMID: 28213833. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6058969/

Biasetti J, Sampath K, Cortez A, Azhir A, Gilad AA,Kickler TS, Obser T, Ruggeri ZM and Katz J. Space and Time Resolved Detection of Platelet Activation and von Willebrand Factor Conformational Changes in Deep Suspensions. International Journal of Biomedical Imaging, vol. 2017, Article ID 8318906, 13 pages, 2017. doi:10.1155/2017/8318906. https://www.hindawi.com/journals/ijbi/2017/8318906/

2016

McMahon, MT and Gilad AA.Cellular and Molecular Imaging Using Chemical Exchange Saturation Transfer. Topics in Magnetic Resonance Imaging: TMRI. 2016 Oct;25(5):197-204. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082432/

Ngen EJ, Bar-Shir A, Jablonska A, Liu G, Song X, Ansari R, Bulte JW, Janowski M, Pearl M, Walczak P,Gilad AA.**Imaging the DNA Alkylator Melphalan by CEST MRI: An Advanced Approach to Theranostics. Mol Pharm. 2016 Sep;13(9):3043-3053. PubMed PMID: 27398883. https://www.ncbi.nlm.nih.gov/pubmed/27398883

Hwang J, Lee E, Kim J, Seo Y, Lee KH, Hong JW, Gilad AA,Park H, Choi J. Effective delivery of immunosuppressive drug molecules by silica coated iron oxide nanoparticles. Colloids Surf B: Biointerfaces. 2016 Jun;142:290-296. doi:10.1016/j.colsurfb.2016.01.040. [Epub ahead of print] PubMed PMID: 26966999 https://www.ncbi.nlm.nih.gov/pubmed/26966999

2015

Andrzejewska A, Nowakowski A, Janowski M, Bulte JW, Gilad AA,Walczak P, Lukomska B. Pre- and postmortem imaging of transplanted cells. Int J Nanomedicine. 2015 Sep 2;10:5543-5559. doi: 10.2147/IJN.S83557. eCollection 2015. Review. PubMed PMID: 26366076; PubMed Central PMCID: PMC4562754 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4562754/

Minn I, Bar-Shir A, Yarlagadda K, Bulte JW, Fisher PB, Wang H, Gilad AA,Pomper MG. Tumor-specific expression and detection of a CEST reporter gene. Magn Reson Med. 2015 Aug;74(2):544-549. doi: 10.1002/mrm.25748. [Epub ahead of print] PubMed PMID: 25919119. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4612624/

Farrar CT, Buhrman JS, Liu G, Kleijn A, Lamfers ML, McMahon MT, Gilad AA,Fulci G. Establishing the Lysine-rich Protein CEST Reporter Gene as a CEST MR Imaging Detector for Oncolytic Virotherapy. Radiology.2015 Jun;275(3):746-754. doi: 10.1148/radiol.14140251. Epub 2015 Feb 13. PubMed PMID: 25686366. https://www.ncbi.nlm.nih.gov/pubmed/25686366

Bar-Shir A, Bulte JW, Gilad AA.** Molecular Engineering of Nonmetallic Biosensors for CEST MRI. ACS Chem Biol. 2015 May 15;10(5):1160-70. doi: 10.1021/cb500923v. Epub 2015 Mar 9. PubMed PMID: 25730583. https://pubs.acs.org/doi/abs/10.1021/cb500923v

Srivastava AK, Kadayakkara DK, Bar-Shir A, Gilad AA,McMahon MT, Bulte JW. Advances in using MRI probes and sensors for in vivo cell tracking as applied to regenerative medicine. Dis Model Mech. 2015 Apr;8(4):323-336. Epub 2015 Apr 1. Review. PubMed PMID: 26035841; PubMed Central PMCID: PMC4381332 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381332/

Bar-Shir A, Liang Y, Chan KW, Gilad AA,Bulte JW. Supercharged green fluorescent proteins as bimodal reporter genes for CEST MRI and optical imaging. Chem Commun (Camb). 2015 Mar 21;51(23):4869-4871. doi: 10.1039/c4cc10195b. PubMed PMID: 25697683; PubMed Central PMCID: PMC4485562. https://www.ncbi.nlm.nih.gov/pubmed/25697683

Song X, Airan RD, Arifin DR, Bar-Shir A, Kadayakkara DK, Liu G, Gilad AA, van Zijl PC, McMahon MT, Bulte JW. Label-free in vivo molecular imaging of underglycosylated mucin-1 expression in tumour cells. Nature Communications.2015 Mar 27;6:6719. doi: 10.1038/ncomms7719. PubMed PMID: 25813863; PubMed Central PMCID: PMC4380237. https://www.ncbi.nlm.nih.gov/pubmed/25813863

Gilad AA,Pelled G. New approaches for the neuroimaging of gene expression. Front Integr Neurosci. 2015 Feb 4;9:5. doi: 10.3389/fnint.2015.00005. eCollection 2015. PubMed PMID: 25698946; PubMed Central PMCID: PMC4316713

Liang Y, Bar-Shir A, Song X, Gilad AA,Walczak P, Bulte JW. Label-free imaging of gelatin-containing hydrogel scaffolds. Biomaterials. 2015 Feb;42:144-150. doi: 10.1016/j.biomaterials.2014.11.050. Epub 2014 Dec 16. PubMed PMID: 25542802; PubMed Central PMCID: PMC4279110. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279110/

Oskolkov N, Bar-Shir A, Chan KW, Song X, van Zijl PC, Bulte JW, Gilad AA,** McMahon MT. Biophysical Characterization of Human Protamine-1 as a Responsive CEST MR Contrast Agent. ACS Macro Lett. 2015 Jan 20;4(1):34-38. Epub 2014 Dec 16. PubMed PMID: 25642384; PubMed Central PMCID: PMC4307908. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4307908/

Bar-Shir A, Yadav NN, Gilad AA,van Zijl PC, McMahon MT, Bulte JW. Single F-19 probe for simultaneous detection of multiple metal ions using miCEST MRI. J Am Chem Soc. 2015 Jan 14;137(1):78-81. doi: 10.1021/ja511313k. Epub 2014 Dec 22. PubMed PMID: 25523816; PubMed Central PMCID: PMC4304440. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4304440/

2014

Jouroukhin Y, Nonyane BA, Gilad AA,Pelled G. Molecular neuroimaging of post-injury plasticity. J Mol Neurosci. 2014 Dec;54(4):630-638. doi: 10.1007/s12031-014-0347-y. Epub 2014 Jun 10. PubMed PMID: 24909382; PubMed Central PMCID: PMC4257867. https://www.researchgate.net/publication/262941833_Molecular_Neuroimaging_of_Post-Injury_Plasticity

Choi J, Park H, Kim T, Jeong Y, Oh MH, Hyeon T, Gilad AA,Lee KH. Engineered collagen hydrogels for the sustained release of biomolecules and imaging agents: promoting the growth of human gingival cells. Int J Nanomedicine. 2014 Nov 11;9:5189-5201. doi: 10.2147/IJN.S71304. eCollection 2014. PubMed PMID: 25429215; PubMed Central PMCID: PMC4243508. https://www.ncbi.nlm.nih.gov/pubmed/25429215

Liu G, Qin Q, Chan KW, Li Y, Bulte JW, McMahon MT, van Zijl PC, Gilad AA.**Non-invasive temperature mapping using temperature-responsive water saturation shift referencing (T-WASSR) MRI. NMR Biomed. 2014 Mar;27(3):320-331. PubMed PMID:  24395616; PubMed Central PMCID: PMC3989428. https://www.ncbi.nlm.nih.gov/pubmed/24395616

Bar-Shir A, Liu G, Chan KW, Oskolkov N, Song X, Yadav NN, Walczak P, McMahon MT, van Zijl PC, Bulte JW, Gilad AA.**Human protamine-1 as an MRI reporter gene based on chemical exchange. ACS Chem Biol. 2014 Jan 17;9(1):134-138. doi: 10.1021/cb400617q. Epub 2013 Oct 25. PubMed PMID: 24138139; PubMed Central PMCID: PMC3985336. https://www.ncbi.nlm.nih.gov/pubmed/24138139

2013

Liu G, Bettegowda C, Qiao Y, Staedtke V, Chan KW, Bai R, Li Y, Riggins GJ, Kinzler KW, Bulte JW, McMahon MT, Gilad AA,Vogelstein B, Zhou S, van Zijl PC. Noninvasive imaging of infection after treatment with tumor-homing bacteria using Chemical Exchange Saturation Transfer (CEST) MRI. Magn Reson Med. 2013 Dec;70(6):1690-1698. doi: 10.1002/mrm.24955. Epub 2013 Oct 7. PubMed PMID: 24123389; PubMed Central PMCID: PMC3857583. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857583/

Bar-Shir A, Liu G, Greenberg MM, Bulte JW, Gilad AA.**Synthesis of a probe for  monitoring HSV1-tk reporter gene expression using chemical exchange saturation transfer MRI. Nature Protocols. 2013 Dec;8(12):2380-2391. doi: 10.1038/nprot.2013.140. Epub 2013 Oct 31. PubMed PMID: 24177294. https://www.ncbi.nlm.nih.gov/pubmed/24177294

Bar-Shir A, Gilad AA,Chan KW, Liu G, van Zijl PC, Bulte JW, McMahon MT. Metal ion sensing using ion chemical exchange saturation transfer F-19 magnetic resonance imaging. J Am Chem Soc.2013 Aug 21;135(33):12164-12167. doi: 10.1021/ja403542g. Epub 2013 Aug 6. PubMed PMID: 23905693; PubMed Central PMCID:  PMC3786336. https://www.ncbi.nlm.nih.gov/pubmed/23905693

Airan RD, Li N, Gilad AA,Pelled G. Genetic tools to manipulate MRI contrast. NMR Biomed. 2013 Jul;26(7):803-809. doi: 10.1002/nbm.2907. Epub 2013 Jan 28.  PubMed PMID: 23355411; PubMed Central PMCID: PMC3669659. https://www.ncbi.nlm.nih.gov/pubmed/23355411

Chan KWY, Liu G, Song X, Kim X, Yu T, Arifin DR, Gilad AA,Hanes J, Walczak P, van Zijl PCM, Bulte JWM and McMahon MT. MRI-detectable pH nanosensors incorporated into hydrogels for in vivo sensing of transplanted cell viability.Nature Materials.2013 Mar;12(3):268-275. doi: 10.1038/nmat3525. Epub 2013 Jan 27. PubMed PMID: 23353626; PubMed Central PMCID: PMC3578129. https://www.ncbi.nlm.nih.gov/pubmed/23353626

Guanshu Liu, Kannie W.Y. Chan, Xiaolei Song, Jiangyang Zhang, Assaf A. Gilad,Jeff W.M. Bulte, Peter C.M. van Zijl, Michael T. McMahon. NOrmalized MAgnetization Ratio (NOMAR) Filtering for Creation of Tissue Selective Contrast Maps. Magnetic Resonance in Medicine. 2013 Feb;69(2):516-523. doi: 10.1002/mrm.24271. Epub 2012 Apr 12. PubMed PMID: 22499503; PubMed Central PMCID: PMC3404207. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3404207/

Bar-Shir A, Liu G, Liang Y, Yadav NN, McMahon MT, Walczak P, Nimmagadda SR, Pomper MG, Tallman KA, Greenberg MM, van Zijl PC, Bulte JW, Gilad AA.**Transforming thymidine into a magnetic resonance imaging probe for monitoring gene expression. J Am Chem Soc.2013 Jan 30;135(4), 1617-1624. [Epub ahead of print] PubMed PMID: 23289583. https://www.ncbi.nlm.nih.gov/pubmed/23289583

2012

Kim H, Walczak P, Kerr C, Galpoththawela C, Gilad AA,Muja N, Bulte JW. Immunomodulation by Transplanted Human Embryonic Stem Cell- Derived Oligodendroglial Progenitors in Experimental Autoimmune Encephalomyelitis. Stem Cells. 2012 Dec;30(12):2820-2829. doi: 10.1002/stem.1218. PubMed PMID: 22949039. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638725/

Airan RD, Bar-Shir A, Liu G, Pelled G, McMahon MT, van Zijl PC, Bulte JW, Gilad AA.**MRI biosensor for protein kinase A encoded by a single synthetic gene. Magn Reson Med. 2012 Nov;68(6):1919-1923. doi: 10.1002/mrm.24483. Epub 2012 Sep 28. PubMed PMID: 23023588; PubMed Central PMCID: PMC3504643. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3504643/

Gorelik M, Orukari I, Wang J, Galpoththawela S, Kim H, Levy M, Gilad AA,Bar-Shir A, Kerr DA, Levchenko A, Bulte JW, Walczak P. Use of MR Cell Tracking to Evaluate Targeting of Glial Precursor Cells to Inflammatory Tissue by Exploiting the Very Late Antigen-4 Docking Receptor. Radiology. 2012 Oct;265(1):175-85. Epub 2012 Aug 24. PubMed PMID: 22923719; PubMed Central PMCID: PMC3447172. https://pubs.rsna.org/doi/full/10.1148/radiol.12112212

Song X, Gilad AA,Joel S, Liu G, Bar-Shir A, Liang Y, Gorelik M, Pekar JJ, van Zijl PC, Bulte JW, McMahon MT. CEST phase mapping using a length and offset varied saturation (LOVARS) scheme. Magn Reson Med. 2012 Oct;68(4):1074-1086. doi: 10.1002/mrm.23312. [Epub ahead of print] PubMed PMID: 22246684. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3336046/

Yadav NN, Jones CK, Xu J, Bar-Shir A, Gilad AA,McMahon MT, van Zijl PC. Detection of rapidly exchanging compounds using on-resonance frequency-labeled exchange (FLEX) transfer. Magn Reson Med. 2012 Oct;68(4):1048-1055. doi: 10.1002/mrm.24420. [Epub ahead of print] PubMed PMID: 22837066. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458160/

Liu G, Moake M, Har-El YE, Long CM, Chan KW, Cardona A, Jamil M, Walczak P, Gilad AA,Sgouros G, van Zijl PC, Bulte JW, McMahon MT. In vivo multicolor molecular MR imaging using diamagnetic chemical exchange saturation transfer liposomes. Magn Reson Med. 2012 Apr;67(4):1106-1113. doi: 10.1002/mrm.23100. [Epub ahead of print] PubMed PMID: 22392814. https://www.ncbi.nlm.nih.gov/pubmed/22392814

2011

Choi J, Kim K, Kim T, Liu G, Bar-Shir A, Hyeon T, McMahon MT, Bulte JW, Fisher JP, Gilad AA.** Multimodal imaging of sustained drug release from 3-D poly(propylene fumarate) (PPF) scaffolds. J Control Release.2011 Dec 10;156(2):239-245. Epub 2011 Jul 8. PubMed PMID: 21763735; PubMed Central PMCID: PMC3202643. https://www.ncbi.nlm.nih.gov/pubmed/21763735

Liu G, Liang Y, Bar-Shir A, Chan KW, Galpoththawela CS, Bernard SM, Tse T, Yadav NN, Walczak P, McMahon MT, Bulte JW, van Zijl PC, Gilad AA.**Monitoring enzyme activity using a diamagnetic chemical exchange saturation transfer magnetic resonance imaging contrast agent. J Am Chem Soc. 2011 Oct 19;133(41):16326-16329. Epub 2011 Sep 23. PubMed PMID: 21919523; PubMed Central PMCID: PMC3201833. https://www.ncbi.nlm.nih.gov/pubmed/21919523

Liu G, Gilad AA.**MRI of CEST-based reporter gene. Methods Mol Biol. 2011;771:733-46. PubMed PMID: 21874505. https://www.ncbi.nlm.nih.gov/pubmed/21874505

Arifin DR, Long CM, Gilad AA,Alric C, Roux S, Tillement O, Link TW, Arepally A, Bulte JW. Trimodal gadolinium-gold microcapsules containing pancreatic islet cells restore normoglycemia in diabetic mice and can be tracked by using US, CT, and positive-contrast MR imaging. Radiology. 2011 Sep;260(3):790-798. Epub 2011 Jul 6. PubMed PMID: 21734156; PubMed Central PMCID: PMC3157003. https://www.ncbi.nlm.nih.gov/pubmed/21734156

Muja N, Cohen ME, Zhang J, Kim H, Gilad AA,Walczak P, Ben-Hur T, Bulte JW. Neural precursors exhibit distinctly different patterns of cell migration upon transplantation during either the acute or chronic phase of EAE: A serial MR imaging study. Magn Reson Med. 2011 Jun;65(6):1738-1749. doi: 10.1002/mrm.22757. Epub 2011 Feb 8. PubMed PMID: 21305597. https://onlinelibrary.wiley.com/doi/pdf/10.1002/mrm.22757

Li N, Downey JE, Bar-Shir A, Gilad AA,Walczak P, Kim H, Joel SE, Pekar JJ, Thakor NV, Pelled G. Optogenetic-guided cortical plasticity after nerve injury. Proc Natl Acad Sci U.S.A.2011 May 24;108(21):8838-8843. Epub 2011 May 9. PubMed PMID: 21555573; PubMed Central PMCID: PMC3102379. https://www.ncbi.nlm.nih.gov/pubmed/21555573

Kim T, Momin E, Choi J, Yuan K, Zaidi H, Kim J, Park M, Lee N, McMahon MT, Quinones-Hinojosa A, Bulte JW, Hyeon T, Gilad AA.**Mesoporous silica-coated hollow manganese oxide nanoparticles as positive T-1 contrast agents for labeling and MRI tracking of adipose-derived mesenchymal stem cells. J Am Chem Soc.2011 Mar 9;133(9):2955-2961. Epub 2011 Feb 11. PubMed PMID: 21314118; PubMed Central PMCID:  PMC3048840. https://www.ncbi.nlm.nih.gov/pubmed/21314118

Kim J, Arifin DR, Muja N, Kim T, Gilad AA,Kim H, Arepally A, Hyeon T, Bulte JW. Multifunctional capsule-in-capsules for immunoprotection and trimodal imaging. Angew Chem Int Ed Engl. 2011 Mar 1;50(10):2317-2321. doi: 10.1002/anie.201007494. Epub 2011 Feb 17. PubMed PMID: 21351344; PubMed Central PMCID: PMC3074433. https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201007494

Walczak P, All AH, Rumpal N, Gorelik M, Kim H, Maybhate A, Agrawal G, Campanelli JT, Gilad AA,Kerr DA, Bulte JW. Human glial-restricted progenitors survive, proliferate, and preserve electrophysiological function in rats with focal inflammatory spinal cord demyelination. Glia. 2011 Mar;59(3):499-510. doi: 10.1002/glia.21119. Epub 2010 Dec 29. PubMed PMID: 21264955; PubMed Central PMCID: PMC3079958. https://www.ncbi.nlm.nih.gov/pubmed/21264955

Berman SC, Galpoththawela C, Gilad AA,Bulte JW, Walczak P. Long-term MR cell  tracking of neural stem cells grafted in immunocompetent versus immunodeficient mice reveals distinct differences in contrast between live and dead cells. Magn Reson Med. 2011 Feb;65(2):564-574. doi: 10.1002/mrm.22613. Epub 2010 Oct 6. PubMed PMID: 20928883; PubMed Central PMCID: PMC3031985. https://www.ncbi.nlm.nih.gov/pubmed/20928883

Liu G, Bulte JW, Gilad AA.CEST MRI reporter genes. Methods Mol Biol. 2011;711:271-80. PubMed PMID: 21279607. https://www.ncbi.nlm.nih.gov/pubmed/21279607

~2010

Liu G, Gilad AA,Bulte JW, van Zijl PC, McMahon MT. High-throughput screening  of chemical exchange saturation transfer MR contrast agents. Contrast Media Mol Imaging. 2010 May-Jun; 5(3):162-70. PubMed PMID: 20586030; PubMed Central PMCID: PMC2898906. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898906/

Kedziorek DA, Muja N, Walczak P, Ruiz-Cabello J, Gilad AA,Jie CC, Bulte JW. Gene expression profiling reveals early cellular responses to intracellular magnetic labeling with superparamagnetic iron oxide nanoparticles. Magn Reson Med. 2010 Apr;63(4):1031-1043. PubMed PMID: 20373404; PubMed Central PMCID: PMC2858578. https://www.ncbi.nlm.nih.gov/pubmed/20373404

Gilad AA,*van Laarhoven HW, McMahon MT, Walczak P, Heerschap A, Neeman M, van Zijl PC, Bulte JW. Feasibility of concurrent dual contrast enhancement using CEST contrast agents and superparamagnetic iron oxide particles. Magn Reson Med. 2009 Apr;61(4):970-974. PubMed PMID: 19189296; PubMed Central PMCID: PMC2743130. https://www.ncbi.nlm.nih.gov/pubmed/19189296

Gilad AA,Ziv K, McMahon MT, van Zijl PC, Neeman M, Bulte JW. MRI reporter genes. J Nucl Med. 2008 Dec;49(12):1905-1908. Epub 2008 Nov 7. Review. PubMed PMID: 18997049; PubMed Central PMCID: PMC2730187. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2730187/

McMahon MT, Gilad AA,DeLiso MA, Berman SM, Bulte JW, van Zijl PC. New “multicolor” polypeptide diamagnetic chemical exchange saturation transfer (DIACEST) contrast agents for MRI. Magn Reson Med. 2008 Oct;60(4):803-812. PubMed  PMID: 18816830; PubMed Central PMCID: PMC2614370. http://europepmc.org/articles/pmc2614370

Gilad AA,Walczak P, McMahon MT, Na HB, Lee JH, An K, Hyeon T, van Zijl PC, Bulte JW. MR tracking of transplanted cells with “positive contrast” using manganese oxide nanoparticles. Magn Reson Med. 2008 Jul;60(1):1-7. PubMed PMID: 18581402; PubMed Central PMCID: PMC2575033. https://www.ncbi.nlm.nih.gov/pubmed/18581402

Walczak P, Zhang J, Gilad AA,Kedziorek DA, Ruiz-Cabello J, Young RG, Pittenger MF, van Zijl PC, Huang J, Bulte JW. Dual-modality monitoring of targeted intraarterial delivery of mesenchymal stem cells after transient ischemia. Stroke. 2008 May;39(5):1569-1574. Epub 2008 Mar 6. PubMed PMID: 18323495; PubMed Central PMCID: PMC2857730. https://www.ncbi.nlm.nih.gov/pubmed/18323495

Walczak P, Kedziorek DA, Gilad AA,Barnett BP, Bulte JW. Applicability and limitations of MR tracking of neural stem cells with asymmetric cell division and rapid turnover: the case of the shiverer dysmyelinated mouse brain. Magn Reson Med. 2007 Aug;58(2):261-9. Erratum in: Magn Reson Med. 2007 Dec; 58(6):1299. PubMed PMID: 17654572. https://onlinelibrary.wiley.com/doi/full/10.1002/mrm.21280

Gilad AA,Winnard PT Jr, van Zijl PC, Bulte JW. Developing MR reporter genes: promises and pitfalls. NMR Biomed. 2007 May;20(3):275-290. Review. PubMed PMID: 17451181. https://www.ncbi.nlm.nih.gov/pubmed/17451181

Gilad AA,McMahon MT, Walczak P, Winnard PT Jr, Raman V, van Laarhoven HW, Skoglund CM, Bulte JW, van Zijl PC. Artificial reporter gene providing MRI contrast based on proton exchange. Nat Biotechnol.2007 Feb;25(2):217-219. Epub 2007 Jan 28. PubMed PMID: 17259977. https://www.ncbi.nlm.nih.gov/pubmed/17259977

Girsh E, Plaks V, Gilad AA,Nevo N, Schechtman E, Neeman M, Dekel N. Cloprostenol, a prostaglandin F-2alpha analog, induces hypoxia in rat placenta: BOLD contrast MRI. NMR Biomed. 2007 Feb;20(1):28-39. PubMed PMID: 16947426. https://www.ncbi.nlm.nih.gov/pubmed/16947426

Neeman M, Gilad AA,Dafni H, Cohen B. Molecular imaging of angiogenesis. J Magn Reson Imaging. 2007 Jan;25(1):1-12. Review. PubMed PMID: 17139635. https://www.ncbi.nlm.nih.gov/m/pubmed/17139635/

Walczak P, Ruiz-Cabello J, Kedziorek DA, Gilad AA,Lin S, Barnett B, Qin L, Levitsky H, Bulte JW. Magnetoelectroporation: improved labeling of neural stem cells and leukocytes for cellular magnetic resonance imaging using a single FDA-approved agent. Nanomedicine. 2006 Jun;2(2):89-94. PubMed PMID: 17292120. https://www.ncbi.nlm.nih.gov/pubmed/17292120

McMahon MT, Gilad AA, Zhou J, Sun PZ, Bulte JW, van Zijl PC. Quantifying exchange rates in chemical exchange saturation transfer agents using the saturation time and saturation power dependencies of the magnetization transfer effect on the magnetic resonance imaging signal (QUEST and QUESP): Ph calibration for poly-L-lysine and a starburst dendrimer. Magn Reson Med.2006 Apr;55(4):836-847. PubMed PMID: 16506187; PubMed Central PMCID: PMC2860536.https://www.ncbi.nlm.nih.gov/pubmed/16506187

Gilad AA,Israely T, Dafni H, Meir G, Cohen B, Neeman M. Functional and molecular mapping of uncoupling between vascular permeability and loss of vascular maturation in ovarian carcinoma xenografts: the role of stroma cells in tumor angiogenesis. Int J Cancer. 2005 Nov 1;117(2):202-211. PubMed PMID: 15880497. https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.21179

Walczak P, Kedziorek DA, Gilad AA,Lin S, Bulte JW. Instant MR labeling of stem cells using magnetoelectroporation. Magn Reson Med. 2005 Oct;54(4):769-74. PubMed PMID: 16161115.

Gilead A,Meir G, Neeman M. The role of angiogenesis, vascular maturation, regression and stroma infiltration in dormancy and growth of implanted MLS ovarian carcinoma spheroids. Int J Cancer. 2004 Feb 10;108(4):524-531. PubMed PMID: 14696116. https://www.ncbi.nlm.nih.gov/pubmed/14696116

Dafni H, Gilead A,Nevo N, Eilam R, Harmelin A, Neeman M. Modulation of the pharmacokinetics of macromolecular contrast material by avidin chase: MRI, optical, and inductively coupled plasma mass spectrometry tracking of triply labeled albumin. Magn Reson Med. 2003 Nov;50(5):904-914. PubMed PMID: 14587000. https://www.ncbi.nlm.nih.gov/pubmed/14587000

Gross S*, Gilead A*,Scherz A, Neeman M, Salomon Y. Monitoring photodynamic therapy of solid tumors online by BOLD-contrast MRI. Nat Med.2003 Oct;9(10):1327-1331. Epub 2003 Sep 21. PubMed PMID: 14502284. https://www.ncbi.nlm.nih.gov/pubmed/14502284

Tempel C, GileadA,Neeman M. Hyaluronic acid as an anti-angiogenic shield in the preovulatory rat follicle. Biol Reprod. 2000 Jul;63(1):134-140. PubMed PMID:10859252. https://www.ncbi.nlm.nih.gov/pubmed/10859252 

GileadA,Neeman M. Dynamic remodeling of the vascular bed precedes tumor growth: MLS ovarian carcinoma spheroids implanted in nude mice. Neoplasia. 1999 Aug;1(3):226-230. PubMed PMID: 10935477; PubMed Central PMCID: PMC1508074. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1508074/